Science - Gut Health - Disease Prevention

Facts

38

By 2040: Increase in <b> colorectal cancer mortality +38%</b> (compared to 2020)<sup><u>18</u></sup>

<sup><u>18</u></sup> Cancer Tomorrow. http://gco.iarc.fr/tomorrow/graphic-isotype?type=1&population=900&mode=population&sex=0&cancer=39&age_group=value&apc_male=0&apc_female=0. Accessed March 10, 2020.

Risikofaktor Ernaehrung

(A western) <b>diet* is the greatest risk factor</b> for chronic digestive diseases <sup><u>1, 5, 6, 7</u></sup>

<sup><u>1</u></sup> Anand P, Kunnumakara AB, Sundaram C, et al. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 2008;25(9):2097-2116. doi:10.1007/s11095-008-9661-9

Mikrobiom Dybiose

Chronic diseases are associated with <b>microbiome dysbiosis</b> <sup><u>8, 9</u></sup>

<sup><u>8</u></sup> Wilkins LJ, Monga M, Miller AW. Defining Dysbiosis for a Cluster of Chronic Diseases. Sci Rep. 2019;9(1). doi:10.1038/s41598-019-49452-y

<b>-30% less microbial species</b> in western microbiomes <sup><u>10, 11</u></sup>

<sup><u>10</u></sup> Obregon-Tito AJ, Tito RY, Metcalf J, et al. Subsistence strategies in traditional societies distinguish gut microbiomes. Nat Commun. 2015;6. doi:10.1038/ncomms7505

50

<More than 50% of all cancers are preventable by a healthy lifestyle <sup><u>1, 2, 3, 4</u></sup>

<sup><u>1</u></sup> Anand P, Kunnumakara AB, Sundaram C, et al. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res.

-160

<b>+160% more days off work</b> due to chronic digestive diseases<sup><u>16</u></sup>

<sup><u>16</u></sup> BKK Dachverband – Interessenverband der Betriebskrankenkassen - BKK Gesundheitsreport. https://www.bkk-dachverband.de/publikationen/bkk-gesundheitsreport.html. Accessed March 10, 2020.

  1. Anand P, Kunnumakara AB, Sundaram C, et al. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 2008;25(9):2097-2116. doi:10.1007/s11095-008-9661-9
  2. Vineis P, Wild CP. Global cancer patterns: Causes and prevention. Lancet. 2014;383(9916):549-557. doi:10.1016/S0140-6736(13)62224-2
  3. WHO | 2. Background. WHO.
  4.  Deutscher Krebskongress 2020: Pressekonferenz Prävention. https://www.krebshilfe.de/informieren/presse/pressemitteilungen/deutscher-krebskongress-2020-pressekonferenz-praevention/. Accessed March 13, 2020.
  5. Forouzanfar MH, Alexander L, Anderson HR, et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386(10010):2287-2323. doi:10.1016/S0140-6736(15)00128-2
  6. Agus A, Denizot J, Thévenot J, et al. Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation. Sci Rep. 2016;6. doi:10.1038/srep19032
  7. Campbell TC. Cancer Prevention and Treatment by Wholistic Nutrition. J Nat Sci. 2017;3(10). http://www.ncbi.nlm.nih.gov/pubmed/29057328. Accessed March 13, 2020.
  8. Wilkins LJ, Monga M, Miller AW. Defining Dysbiosis for a Cluster of Chronic Diseases. Sci Rep. 2019;9(1). doi:10.1038/s41598-019-49452-y
  9. Blaser MJ, Falkow S. What are the consequences of the disappearing human microbiota? Nat Rev Microbiol. 2009;7(12):887-894. doi:10.1038/nrmicro2245
  10. Obregon-Tito AJ, Tito RY, Metcalf J, et al. Subsistence strategies in traditional societies distinguish gut microbiomes. Nat Commun. 2015;6. doi:10.1038/ncomms7505
  11. Rampelli S, Schnorr SL, Consolandi C, et al. Metagenome Sequencing of the Hadza Hunter-Gatherer Gut Microbiota. Curr Biol. 2015;25(13):1682-1693. doi:10.1016/j.cub.2015.04.055
  12. Wu GD, Chen J, Hoffmann C, et al. Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes. Science (80- ). 2011;334(6052):105-108. doi:10.1126/science.1208344
  13. David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559-563. doi:10.1038/nature12820
  14. Canavan C, West J, Card T. The epidemiology of irritable bowel syndrome. Clin Epidemiol. 2014;6(1):71-80. doi:10.2147/CLEP.S40245
  15. Althaus A, Broicher W, Wittkamp P, Andresen V, Lohse AW, Löwe B. Determinants and frequency of irritable bowel syndrome in a German sample. Z Gastroenterol. 2016;54(3):217-225. doi:10.1055/s-0041-106856
  16. BKK Dachverband – Interessenverband der Betriebskrankenkassen – BKK Gesundheitsreport. https://www.bkk-dachverband.de/publikationen/bkk-gesundheitsreport.html. Accessed March 10, 2020.
  17. Meddings JB, Swain MG. Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat. Gastroenterology. 2000;119(4):1019-1028. doi:10.1053/gast.2000.18152
  18. Cancer Tomorrow. http://gco.iarc.fr/tomorrow/graphic-isotype?type=1&population=900&mode=population&sex=0&cancer=39&age_group=value&apc_male=0&apc_female=0. Accessed March 10, 2020.
  19. Functional Gastrointestinal Disorders: Novel Insights and Treatments. https://www.medscape.com/viewarticle/717346_3. Accessed March 13, 2020.
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